NAD, Niacin, Resveratrol

A good book with leading edge info on NAD+ is Lifespan, by David Sinclair. Here is my Kindle Review and My highlights and notes from Kindle

I also find it fascinating that celebrated kook and Scientology founder L. Ron Hubbard had an extreme Niacin detox program in a book (more notes here).

Unrelated I used to take Niacin, it gives an uncomfortable “flush” that takes a while to get used to – especially if you exercise after taking it.  I’ve read elsewhere that Niacin can damage organs, I’m not taking it at present.

Sinclair’s specific recommendations

  • Low levels of leucine, isoleucine, and violin BCAAs correlate with increased lifespan
  • Exercise turns on the genes that make us young again
  • Hunger and calorie restriction plays a big role in vitality and longevity
  • Get exposed to cold
  • Shift to vegetarian/vegan diet 
  • Sauna 7x a week may be great
  • NMN molecule boosts NAD – he takes it in supplements + Metformin 
  • Nicotinamide Riboside (NR) is converged to NMN, it’s cheaper, but it doesn’t raise NAD levels as well as MNM does
  • Rapamycin is very powerful, but still very toxic for you
  • Stoke development of brown fat (it activates when you get cold – my notes on swimming)

What David Sinclair does:

  • 1g (1000 milligrams) of NMN+ 1g of resveratrol shaken into his homemade yogurt every morning
  • 1g of Metformin
  • Daily doze of vitamin D, vitamin K2
  • 83mg of aspirin 
  • Keeps sugar, bread and pasta intake as low as possible, no deserts
  • skips one meal a day (largely skips lunch)
  • Tests blood for dozens of biomarkers every few months and moderates them with food and exercise if not optimal levels 
  • Takes a lot of steps and runs up stairs daily
  • Exercises, Sauna, cold plunge pool
  • Mostly plant-based diet
  • Avoids microwave plastic, excessive UV exposure, X-rays and CT scans
  • No smoking
  • Stays in the cool side during the day and when he sleeps at night
  • Keeps his BMI: 23-25
  • Supplements: only from a large manufacturers with good reputation, seek highly pure molecules: >98%; looks for GMP on the label (Good Manufacturing Practices)

 

What I (and people I that I know) do

Scott takes: https://biogency.com.au/product/synext/ NMA only 100mg, contains nicotinamide. At 58:20 of this video it suggests nicotinamide is not good.
Andrew takes NMN and Resveratrol https://www.prohealthlongevity.com/collections/nmn/products/prohealth-nmn-pro-300-3-pack-ph518c This looks really good but when I looked extremely expensive in Australia, its reasonable in the US.

https://www.herbsofgold.com.au/products/antioxidants/resveratrol-advantage

I take Nicotinamide Riboside (NR) and Resveratol NR: https://www.truniagen.com.au/ – Sinclair criticises the stability of NR when not cold stored. Refer to this video at 58:30, here . I quizzed True Niagen, here is their response.

** Text at bottom of page

Use Trans-Resveratol, its very insoluble so include with fat (yoghurt). Light Sensitive (needs to be kept in dark/cold). I buy  this.


** No we wouldn’t necessarily agree as TRU NIAGEN® is formulated with a crystalline form of nicotinamide riboside chloride.
This crystalline form is shelf stable when stored under the recommended conditions listed on the TRU NIAGEN® bottle and can tolerate fluctuating and elevated temperatures (even up to 40C) for periods of time.
ChromaDex specifically formulates TRU NIAGEN® this way to enhance the overall stability and quality.
If you were to be storing Tru Niagen in warm temperatures for months on end, then we’d always recommend keeping in a cool, dry place (or even the fridge) to ensure stability and efficacy through to the BB date.