A good book with leading edge info on NAD+ is Lifespan, by David Sinclair. Here is my Kindle Review and My highlights and notes from Kindle
I also find it fascinating that celebrated kook and Scientology founder L. Ron Hubbard had an extreme Niacin detox program in a book (more notes here).
Unrelated I used to take Niacin, it gives an uncomfortable “flush” that takes a while to get used to – especially if you exercise after taking it. I’ve read elsewhere that Niacin can damage organs, I’m not taking it at present.
Sinclair’s specific recommendations
- Low levels of leucine, isoleucine, and violin BCAAs correlate with increased lifespan
- Exercise turns on the genes that make us young again
- Hunger and calorie restriction plays a big role in vitality and longevity
- Get exposed to cold
- Shift to vegetarian/vegan diet
- Sauna 7x a week may be great
- NMN molecule boosts NAD – he takes it in supplements + Metformin
- Nicotinamide Riboside (NR) is converged to NMN, it’s cheaper, but it doesn’t raise NAD levels as well as MNM does
- Rapamycin is very powerful, but still very toxic for you
- Stoke development of brown fat (it activates when you get cold – my notes on swimming)
What David Sinclair does:
- 1g (1000 milligrams) of NMN+ 1g of resveratrol shaken into his homemade yogurt every morning
- 1g of Metformin
- Daily doze of vitamin D, vitamin K2
- 83mg of aspirin
- Keeps sugar, bread and pasta intake as low as possible, no deserts
- skips one meal a day (largely skips lunch)
- Tests blood for dozens of biomarkers every few months and moderates them with food and exercise if not optimal levels
- Takes a lot of steps and runs up stairs daily
- Exercises, Sauna, cold plunge pool
- Mostly plant-based diet
- Avoids microwave plastic, excessive UV exposure, X-rays and CT scans
- No smoking
- Stays in the cool side during the day and when he sleeps at night
- Keeps his BMI: 23-25
- Supplements: only from a large manufacturers with good reputation, seek highly pure molecules: >98%; looks for GMP on the label (Good Manufacturing Practices)
What I (and people I that I know) do
| Scott takes: https://biogency.com.au/product/synext/ | NMA only 100mg, contains nicotinamide. At 58:20 of this video it suggests nicotinamide is not good. |
| Andrew takes NMN and Resveratrol | https://www.prohealthlongevity.com/collections/nmn/products/prohealth-nmn-pro-300-3-pack-ph518c This looks really good but when I looked extremely expensive in Australia, its reasonable in the US. |
| I take Nicotinamide Riboside (NR) and Resveratol | NR: https://www.truniagen.com.au/ – Sinclair criticises the stability of NR when not cold stored. Refer to this video at 58:30, here . I quizzed True Niagen, here is their response.
** Text at bottom of page Use Trans-Resveratol, its very insoluble so include with fat (yoghurt). Light Sensitive (needs to be kept in dark/cold). I buy this. |
** No we wouldn’t necessarily agree as TRU NIAGEN® is formulated with a crystalline form of nicotinamide riboside chloride.
This crystalline form is shelf stable when stored under the recommended conditions listed on the TRU NIAGEN® bottle and can tolerate fluctuating and elevated temperatures (even up to 40C) for periods of time.
ChromaDex specifically formulates TRU NIAGEN® this way to enhance the overall stability and quality.
If you were to be storing Tru Niagen in warm temperatures for months on end, then we’d always recommend keeping in a cool, dry place (or even the fridge) to ensure stability and efficacy through to the BB date.